Fast-spiking interneurons have an initial orientation bias that is lost with vision
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چکیده
منابع مشابه
Functional Properties of Striatal Fast-Spiking Interneurons
Striatal fast-spiking interneurons (FSIs) have a major influence over behavioral output, and a deficit in these cells has been observed in dystonia and Tourette syndrome. FSIs receive cortical input, are coupled together by gap junctions, and make perisomatic GABAergic synapses onto many nearby projection neurons. Despite being critical components of striatal microcircuits, until recently littl...
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21 Tonically-activated neuronal currents mediated by N-methyl-D-aspartate receptors (NMDARs) 22 have been hypothesized to contribute to normal neuronal function as well as to neuronal 23 pathology resulting from excessive activation of glutamate receptors (e.g., excitotoxicity). While 24 cortical excitatory cells are very vulnerable to excitotoxic insult, the data regarding resistance of 25 inh...
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Prefrontal cortical dopamine (DA) modulates pyramidal cell excitability directly and indirectly by way of its actions on local circuit GABAergic interneurons. DA modulation of interneuronal functions is implicated in the computational properties of prefrontal networks during cognitive processes and in schizophrenia. Morphologically and electrophysiologically distinct classes of putative GABAerg...
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We examine how the location of weak electrical coupling affects phase-locking in a pair of model fast-spiking interneurons. Each model neuron consists of a somatic compartment and a passive dendritic compartment. At relatively low frequencies, the phase-locking structure for somatic and dendritic coupling is qualitatively the same: below a critical frequency, stable synchronous and anti-phase a...
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GABAergic interneurons appear to play a fundamental role in the functioning of the neostriatum by modulating the spiking of striatal projection neurons with great efficacy. The powerful and strongly divergent output of the GABAergic interneurons neurons suggests that modulation of their activity may be particularly effective at controlling the functioning of the entire neostriatal circuitry. Ac...
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ژورنال
عنوان ژورنال: Nature Neuroscience
سال: 2011
ISSN: 1097-6256,1546-1726
DOI: 10.1038/nn.2890